-科研成果
l Lai HC, Chang CJ, Yang CH, Hsu YJ, Chen CC, Lin CS, Tsai YH, Huang TT, Ojcius DM, Tsai YH, Lu CC*. Activation of NK cell cytotoxicity by the natural compound 2,3-butanediol. Journal of Leukocyte Biology 2012 Oct;92 (4):807-14. (SCI, IF=6.011)
l Chang CJ, Chen YY, Lu CC, Lin CS, Martel J, Tsai SH, Ko YF, Huang TT, Ojcius DM, Young JD*, Lai HC*. Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin. Innate Immunity. 2014 Apr; 20(3):301-11 (SCI, IF=2.951, First author)
l Huang TT, Lai HC, Chen YB, Chen LG, Wu YH, Ko YF, Lu CC, Chang CJ, Wu CY, Martel J, Ojcius DM, Chong KY*, Young JD*. Cis-Resveratrol produces anti-inflammatory effects by inhibiting canonical and non-canonical inflammasomes in macrophage. Innate Immunity. 2014;20:735-50. (SCI, IF=2.951)
l Chun-Hung Yang, Hui-Ling Wang, Yi-Sheng Lin, K.P. Shravan Kumar, Hung-Chi Lin, Chih-Jung Chang, Chia-Chen Lu, Tsung-Teng Huang, Jan Martel, David M. Ojcius, Yu-Sun Chang, John D. Young* and Hsin-Chih Lai*. Identification of CD24 as a cancer stem cell marker in human nasopharyngeal carcinoma. Plos one 2014 Jun 23;9(6):e99412 (SCI, IF=3.752)
l Chia-Chen Lu, Ting Shu Wu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Ju-Hsin Chia, Tsu-Lan Wu, Tsung-Teng Huang, Jan Martel, David Ojcius, John D. Young* and Hsin-Chih Lai*. Direct perforin-dependent killing of mycobacteria by NK cells. Journal of Leukocyte Biology 2014 Dec;96(6):1119-29 (SCI, IF=6.011)
l Chuan-Sheng Lin#, Chih-Jung Chang#, Chia-Chen Lu, Jan Martel, David M. Ojcius, Yun-Fei Ko, John D.Young*, Hsin-Chih Lai*. Impact of the gut microbiota, prebiotics, and probiotics on human health and disease. Biomedical Journal 2014 Sep-Oct; 37(5):259-68 (SCI, IF=7.892, Co-first author)
l Chih-Jung Chang, Gut microbiota, Obesity and Traditional Chinese Medicine. Journal of Biomedical & Laboratory Sciences, 2014.
l Chih-Jung Chang#, Chuan-Sheng Lin#, Chia-Chen Lu, Jan Martel, Yun-Fei Ko, David M. Ojcius, Shun-Fu Tseng, Tsung-Ru Wu, Yi-Yuan Margaret Chen, John D. Young* & Hsin-Chih Lai*. Ganoderma lucidum mycelium modulates the gut microbiota and reduces obesity in mice. Nature Communications. 2015 Jun 23;6:7489 (SCI, IF=17.694, first author)
l Chia-Chen Lu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Jan Martel, David M Ojcius, Yun-Fei Ko, Hsin-Chih Lai*, John D Young*. Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity. Innate Immunity. 2016 Oct;22(7):522-33.( SCI, IF=2.951)
l Chuan-Sheng Lin, Yu-Huan Tsai, Chih-Jung Chang, Shun-Fu Tseng, Tsung-Ru Wu, Chia-Chen Lu, Ting-Shu Wu, Jang-Jih Lu, Jim-Tong Horng, Jan Martel, David M. Ojcius, Hsin-Chih Lai& John D. Young*. An iron detection system determines bacterial swarming initiation and biofilm formation. Scientific Reports 2016 Nov 15;6:36747. (SCI, IF=4.996)
l Chuan-Sheng Lin, Chih-Jung Chang, Jan Martel, David M. Ojcius, Wei-Fan Lai, Chia-Chen Lu, Yun-Fei Ko, John D.Young*, Hsin-Chih Lai. Lipopolysaccharide: friend of foe? Journal of Biomedical & Laboratory Sciences. 2016;28:121
l Jan Martel, David M. Ojcius, Chih-Jung Chang, Chuan-Sheng Lin, Chia-Chen Lu, Yun-Fei Ko, Shun-Fu Tseng, Hsin-Chih Lai* & John D. Young*. Anti-obesogenic and antidiabetic effects of plants and mushrooms. Nature Review Endocrinology. 2017 Mar;13(3):149-160. (SCI, IF=47.564)
l Wei CF, Tsai YH, Tsai SH, Lin CS, Chang CJ, Lu CC, Huang HC, Lai HC. Cross-talk between bacterial two-component systems drives stepwise regulation of flagellar biosynthesis in swarming development. Biochem Biophys Res Commun. 2017 Jul 15;489(1):70-75 (SCI, IF=3.322)
l Martel J, Ko YF, Ojcius DM, Lu CC, Chang CJ, Lin CS, Lai HC, Young JD. Immunomodulatory Properties of Plants and Mushrooms. Trends Pharmacol Sci. 2017 Nov;38(11):967-981 (SCI, IF=17.638)
l Schachter J, Martel J, Lin CS, Chang CJ, Wu TR, Lu CC, Ko YF, Lai HC, Ojcius DM, Young JD. Effects of obesity on depression: A role for inflammation and the gut microbiota. Brain Behav Immun. 2017 Sep 6. pii: S0889-1591(17)30415-4 (SCI, IF=19.227)
l Chang CJ, Lu CC, Lin CS, Martel J, Ko YF, Ojcius DM, Wu TR, Tsai YH, Yeh TS, Lu JJ, Lai HC, Young JD. Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. Int J Obes (Lond). 2018 Feb;42(2):231-243 (SCI, IF=5.551, First author)
l Lai HC, Chang CJ, Lin CS, Wu TR, Hsu YJ, Wu TS, Lu JJ, Martel J, Ojcius DM, Ku CL, Young JD, Lu CC. NK Cell-Derived IFN-γ Protects against Nontuberculous Mycobacterial Lung Infection. J Immunol. 2018 Sep 1;201(5):1478-1490. (SCI, IF=5.426)
l Wu TR#, Lin CS#, Chang CJ#, Lin TL, Martel J, Ko YF, Ojcius DM, Lu CC, Young JD, Lai HC. Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis. Gut. 2019 Feb;68(2):248-262 (SCI, IF=31.793, co-first author)
l Tsai YL, Lin TL, Chang CJ, Wu TR, Lai WF, Lu CC, Lai HC. Probiotics, prebiotics and amelioration of diseases. J Biomed Sci. 2019 Jan 4;26(1):3 (SCI, IF=12.771, co-first author)
l Martel J, Ojcius DM, Ko YF, Chang CJ, Young JD. Antiaging effects of bioactive molecules isolated from plants and fungi. Med Res Rev. 2019 Sep;39(5):1515-1552 (SCI, IF=12.338)
l Chih-Jung Chang, Tzu-Lung Lin, Yu-Ling Tsai, Tsung-Ru Wu, Wei-Fan Lai, Chia-Chen Lu and Hsin-Chih Lai. Next generation probiotics in disease amelioration. J Food Drug Anal. 2019 Jul;27(3):615-622.(SCI, IF=6.157, First author)
l Yu-Ling Tsai, Wen-Chiuan Tsai, ZhuQing, Chih-Jung Chang.
Dichotomous effects of microbial membrane vesicles on the regulation of
immunity. Medicine in Microecology, 2020 March, Corresponding author)
l Chang CJ, Chen CB, Hung SI, Ji C, Chung WH. Pharmacogenetic Testing for Prevention of Severe Cutaneous Adverse Drug Reactions. Front Pharmacol 2020 Jul 2;11:969 (SCI, IF=5.988, First author)
l Hsin-Chih Lai, Tzu-Lung Lin, Ting-Wen Chen, Yu-Lun Kuo, Chih-Jung Chang Tsung-Ru Wu, Ching-Chung Shu, Ying-Huang Tsai, Simon Swift, Chia-Chen Lu. Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide. Gut. 2022;71(2):309-321 (SCI, IF=31.793)
l Yu-Chieh Weng, Wei-Ting Chen, Jung-Chieh Lee, Yung-Ning Huang, Chih-Kai Yang, Hui-Shan Hsieh, Chih-Jung Chang, Yang-Bor Lu. Intestinal fatty acid-binding protein is a biomarker for diagnosis of biliary tract infection. JGH Open. 2021;5:1160 (SCI, IF=1.66, co-Corresponding author)
l Chang CJ, Wang H, Zhang J, Zou Y, Zhang Y, Chen J, Chen CB, Chung WH, Ji C. Distinct proteomic profiling of plasma extracellular vesicles from moderate-to-severe atopic dermatitis patients. Clin Cosmet Investig Dermatol. 2021;14:1033 (SCI, IF=2.765, First author)
l Chih-Jung Chang, Jing Zhang, Yu-Ling Tsai, Chun-Bing Chen, Chun-Wei Lu, Yu-Ping Huo, Huey-Ming Liou, Chao Ji *, Wen-Hung Chung *. Compositional Features of Distinct Microbiota Base on Serum Extracellular Vesicle Metagenomics Analysis in Moderate to Severe Psoriasis Patients. Cells. 2021;10:2349 (SCI, IF=7.66, First author)
l Tsai-Yeh, Chiang, Yu-Ru Yang, Ming-Ying Zhuo, Feng Yang, Ying-Fei Zhang, Chia-Hsiang Fu, Ta-Jen Lee, Wen-Hung Chung, Liang Chen, Chih-Jung Chang. Microbiome profiling of nasal extracellular vesicles in patients with allergic rhinitis. World Allergy Organization Journal 2022; 15:100674 (SCI, IF=5.6, Corresponding author)
l Wang CW, Chi MH, Tsai TF, Yu KH, Kao HW, Chen HC, Chen CB, Lu CW, Chen WT, Chang YC, Chang CJ, Chang YT, Jan Wu YJ, Chang CJ, Huang YH, Ng CY, Huang PW, Lin YJ, Hui RC, Chung WH. Implementation of NUDT15 genotyping to prevent Azathioprine-induced leukopenia for patients with autoimmune disorders in Chinese population. Clin Pharmacol Ther 2022 Jul 22. doi: 10.1002/cpt.2716. (SCI, IF=6.903)
l Lu CW, Pang JS, Ko YS, Chang CJ, Wang CW, Chen WT, Chen CB, Hui RC, Hung SI, Lu LY, Lu KL, Wang CL, Wu CE, Hsu PC, Fang YF, Li SH, Ko HW, Tseng LC, Shih FY, Chen MJ, Chung WH. Zinc deficiency associated with cutaneous toxicities induced by epidermal growth factor receptor tyrosine kinase inhibitor therapy in patients with lung adenocarcinoma. J Eur Acad Dermatol Venereol. 2022 Nov 10. doi: 10.1111/jdv.18703 (SCI, IF=9.228)
l Wang CW, Lin WC, Chen WT, Chen CB, Lu CW, Hou HH, Hui RC, Wu J, Chang CJ, Chang YC, Chung WH; Taiwan Severe Cutaneous Adverse Reaction Consortium. Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population. Front Pharmacol. 2022 Nov 25;13:954596 (SCI, IF=5.988)
l Qi-Wen Ma, Chun-Wei Lu , Chun- Bing Chen Liang Chen, Guo-Dong Ye , Wen- Hung Chung, Chih-Jung Chang. Next-Generation Probiotics and Secreted Extracellular Vesicles in Disease Amelioration. Research & Reviews: Journal of Microbiology and Biotechnology (2023)
l Haifeng Hong, Changhui Lin, Min Fang, Juntian Liu, Hung-Chih Hsu, Chih-Jung Chang, Haibing Wang. Proteomic analysis of exosomal proteins associated with bone healing speed in a rat tibial fracture model. BIOMEDICAL CHROMATOGRAPHY(SCI, IF=1.8, Corresponding author)
专利:
专利申请:
美国:
Ø US9757409B2_Method to prepare Ganoderma lucidum polysaccharides possessing insulin-sensitizing properties and applications thereof
Ø US9758595B2_Method to prepare Ganoderma lucidum polysaccharides possessing anti-obesity properties and uses thereofMethod to prepare Ganoderma lucidum polysaccharides possessing protective activities on fatty liver disease
Ø US9763990_Method to prepare Ganoderma lucidum polysaccharides possessing protective activities on fatty liver diseaseMethod to prepare Hirsutella sinensis polysaccharides possessing insulin-sensitizing properties and applications thereof
Ø US9828442_Method to prepare Hirsutella sinensis polysaccharides possessing insulin-sensitizing properties and applications thereofMethod to reduce body weight, fat accumulation and adipocyte size using Parabacteroides goldsteinii
Ø US10086019B1Method to reduce insulin resistance and improve glucose tolerance using Parabacteroides goldsteinii
Ø US10111915B1_Method to treat fatty liver disease using Parabacteroides goldsteinii
Ø US20160361348A1_Method to prepare hirsutella sinensis polysaccharides possessing anti-obesity properties and uses thereof
Ø US20160361370A1_Method to prepare Hirsutella sinensis polysaccharides possessing protective activities on fatty liver disease
大陆:
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美国:
Ø US9757409B2_Method to prepare Ganoderma lucidum polysaccharides possessing insulin-sensitizing properties and applications thereof
Ø US9758595B2_Method to prepare Ganoderma lucidum polysaccharides possessing anti-obesity properties and uses thereof
Ø US9763990_Method to prepare Ganoderma lucidum polysaccharides possessing protective activities on fatty liver disease
Ø US9828442_Method to prepare Hirsutella sinensis polysaccharides possessing insulin-sensitizing properties and applications thereof
Ø US9956255B1Method to reduce body weight, fat accumulation and adipocyte size using Parabacteroides goldsteinii
Ø US10086019B1Method to reduce insulin resistance and improve glucose tolerance using Parabacteroides goldsteinii
Ø US10111915B1_Method to treat fatty liver disease using Parabacteroides goldsteinii
Ø US20160361348A1_Method to prepare hirsutella sinensis polysaccharides possessing anti-obesity properties and uses thereof
Ø US20160361370A1_Method to prepare Hirsutella sinensis polysaccharides possessing protective activities on fatty liver disease
